Endocrine Abstracts

Introduction: Recently, the immune hypothesis of depression has gained a new dimension because of inflammasomes. NLRP3 inflammasome is a protein complex and its activation leads to stimulation of the enzyme caspase 1 responsible for generation of active form of pro-inflammatory cytokines: IL-1 β and IL-18. Recently postulated ‘inflammasome theory of depression’ assumes that depression is based on a disturbance of the mechanisms regulating NLRP3 complexes and unc...